氨基末端前體腦鈉肽與左室舒張功能的相關性研究.pdf

1、青島大學碩士學位論文氨基末端前體腦鈉肽與左室舒張功能的相關性研究姓名：郭潔申請學位級別：碩士專業(yè)：心血管內科學指導教師：沃金善20080601AbstractAIM：ToinvestigatetherelationshipbetweenNterminalprobrainnatriureticpeptide(NT—proBNP)andleftventriculardiastolicfunctionMETHODS：①Fiftythreepa

2、tientswithisolateddiastolicdysfunctionandpreservedleftventricularejectionfractionandthirtyfourpatientswithregularleftventricularfunctionasnormalcontrolwereexaminedbyconventionalechocardiography，tissueDopplerimaging，andle

3、ftheartcatheterization②趟lthesubjectswerestudiedv／aelectrochemicalradiationtotestNT—proBNPlevels；Echocardiogram，tissueDopplerimagingandleftheartcatheterizationwereappliedtodetecttheparameterstoreflectleftventriculardiasto

4、licfunction；thecorrelationofNTproBNPlevelsandthediastolicfunctionparameterswasalsoanalyzedRESULTS：①NTproBNPplasmalevelswereelevated【106401458985pg／ml(22324569pg／m1)VS617944576pg／ml(684—1322pg／m1)；P0001】andincreasedwithgr

5、eaterseverityofthediastolicdysfunction(R=O71，P0001)②Leftventricularend—diastolicpressure(areaunderthecurve(AUC)082)wasthemostspecificparameterwhichhadalowsensitivity(73％)，howeverThereliabilityofNTproBNPWassimilartotissue

6、Dopplerimagingindices(AUC076vs077)andimprovedwhencomparedwithconventionalechocardiography(AUC060—075)NTproBNPlevelshadthebestnegativepredictivevalueofallmethods(93％)andcorrelatedstronglywithindicesofleftventricularend—di

7、astolicpressure(R=048，P0001)，asdeterminedbyinvasivemeasurementsMultivariablelinearregressionanalysisconfirmedNTproBNPasanindependentpredictorofdiastolicdysfunctionwithanOddsratioof1237(1019—1427，CI95％)CONCLUSIO：NT—proBNP

8、canreliablydetectthepresenceofisolateddiastolicdysfunctioninsymptomaticpatientsPostgraduatestudent：GuoJie(Cardiology)DirectedbyAssociateprofWoJinshanKEYWORDS：Leftventricularfunction；Diastolicfunction；Nterminalpro—B毋penat