MMP2、MMP9和VEGF在非小細(xì)胞肺癌中的表達(dá)及其與臨床病理特征的關(guān)系.pdf

1、遵義醫(yī)學(xué)院碩士學(xué)位論文MMP2、MMP9和VEGF在非小細(xì)胞肺癌中的表達(dá)及其與臨床病理特征的關(guān)系姓名：田東波申請學(xué)位級別：碩士專業(yè)：呼吸內(nèi)科指導(dǎo)教師：楊渝浩2002.4.1縫塞M＆堡≥：M鯉墮塑旦：壁壅韭塵墅墮壁蕉生鯉塞姿壁基墨!墮匿亙堡簦塹盟羞丕————墨lTherelationshipbetweenMMP2，MMP9，VEGFexpressionandclinicpathologicalfeaturesinnonsmall。cell

2、hmgcarcinomaAbstractObjectiveToinvestigatetherelationshipbetweenMMP2，MMP9，VEGFandclinicpathologicalfeaturesinnon—small—celllungcarcinomaMethodsMMP2，MMP9andVEGFexpressionsweredeterminedinsurgically打emed77easesofnonsmallce

3、lllungcarcinomatissuesandtheiradjacenttissuesand24GasesofnormallungtissuesbystreptavidinperoxdaseimmunohistochemicaltechniqueTherelationshipsbetweentheoverexpressionsofMMP2MMP9，VEGFandtumortypes，clinicalstages，pathologic

4、algrades，lymphnodemetastasis，tumorsize，smokinghistory，age，sexaswellasthecorrelationamoungtheoverexpressionsofMMP2，MMP9，VEGFwereanalyzedbychisquardtestSurvivalcurveswereplottedaccordingtotheKaplanMeierestimatesSurvivalrat

5、edifferencesbetweenoverexpressionsandnod—overexpressionsofMMP2，MMP9，VEGFwereanalyzedbyLogranktestResultsTheimmunoreactivitiesofMMP2MMP9，VEGFweremainlyshownincytoplasmaoftumorcellsTheoverexpressionsofMMP2，MMP9，VEGFincarci

6、nomatissuesweresignificantlyhigherthaninadjacenttissues(p0005)NooverexpressionwasobservedinnormaltissuesBystastisticalanalysis，theiroverexpressionswerenotrelatedtotlllllortypes，clinicalstages，pathologicalgrades，sex，age，s